Aging Research News Feed

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Aging Pathway

Therapeutic

A beneficial compound produced by the probiotic bacterium Bacillus velezensis DS2 activates a specific signaling pathway, which strengthens gut immunity and reduces age-related inflammation in older mice.

Jan 7, 2026

Gemini

Age-Dependent Reprogramming Of Vascular Metabolism Compromises Endothelial Resilience To Inflammation-Induced Endothelial Dysfunction

Aging Theory

Aging Pathway

Therapeutic

Aging causes changes in how the cells lining blood vessels produce energy, making these vessels less able to resist damage from inflammation.

Jan 7, 2026

Gemini

Anti-Aging Effects Of The Adrenal Androgens Dehydroepiandrosterone And Dehydroepiandrosterone Sulfate: Mechanisms Of Action And Beneficial Effects In Older People

Aging Pathway

Therapeutic

Adrenal hormones dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) decrease with age and are associated with various beneficial effects on health, including supporting the immune system, bone density, and cognitive function.

Jan 7, 2026

Gemini

Disrupted Riboflavin Metabolism Impairs Circadian Rhythm In Ovarian Granulosa Cells: A Novel Mechanism Driving DOR

Aging Pathway

Therapeutic

Disrupted riboflavin metabolism impairs the body’s internal clock in ovarian cells, offering a new explanation for diminished ovarian reserve.

Jan 7, 2026

Gemini

Clock

Analytical

A large international study has revealed a shared genetic foundation underlying the difference between a person’s predicted brain age and their actual age, identifying specific genetic markers linked to this “brain age gap” and various health conditions.

Jan 7, 2026

Gemini

Stage-Specific Expression Of Histone Deacetylases In The Mouse Mandibular Condylar Cartilage

Aging Pathway

A study identified the specific patterns of histone deacetylase enzyme expression in the cartilage of the mouse jaw joint at different stages of aging.

Jan 7, 2026

Gemini

The Role Of Gut Microbiome In Aging-Associated Diseases: Where Do We Stand Now And How Technology Will Transform The Future

Aging Pathway

Therapeutic

Analytical

The gut microbiome plays a crucial role in human aging and overall health, with age-related imbalances in gut microbes contributing to a broad spectrum of diseases associated with aging.

Jan 7, 2026

Gemini

Cancer-Cell-Secreted Ddah1 Induces TGF-Β1/Smad3 Signaling Pathway To Promote Fibrosis And Aging In Lung

Aging Pathway

Therapeutic

Cancer cells release a protein called DDAH1, which causes an increase in citrulline, subsequently activating the TGF-β1/Smad3 signaling pathway to accelerate lung scarring and aging.

Jan 5, 2026

Gemini

Clonal Hematopoiesis Is Associated With Future Diseases And Mortality

Aging Theory

Aging Pathway

Analytical

A common age-related condition where blood cells carry specific genetic mutations, known as clonal hematopoiesis, is linked to an increased risk of various diseases across multiple body systems and higher mortality.

Jan 5, 2026

Gemini

Aging Theory

Aging Pathway

Analytical

A study combining gene expression and network connectivity analyses revealed that genes involved in RNA splicing and processing are commonly altered with age across various human tissues.

Jan 3, 2026

Gemini

Aging Pathway

The environmental contaminants Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and its metabolite Bis(1,3-dichloro-2-propyl) phosphate (BDCPP) disrupt reproduction, metabolism, and accelerate aging in the model organism Caenorhabditis elegans, with TDCPP generally showing more pronounced effects.

Jan 1, 2026

Gemini

Epigenetics Of Glaucoma In The Trabecular Meshwork

Aging Pathway

Therapeutic

Epigenetic mechanisms, which involve changes in gene activity without altering the underlying DNA sequence, play a significant role in the dysfunction of the trabecular meshwork in glaucoma, integrating environmental factors and aging into disease progression.

Jan 1, 2026

Gemini

The Emerging Triad In Cancer And Aging: Cellular Senescence, Microbiome, And Tumor Microenvironment

Aging Theory

Aging Pathway

Therapeutic

Lever

Analytical

The paper introduces a unified concept explaining how aging-related cancer development and treatment response are influenced by the complex interplay between non-dividing cells, the surrounding environment of a tumor, and the body’s microbial communities.

Jan 1, 2026

Gemini

Aging Pathway

A new research model demonstrates that administering D-galactose, a type of sugar, can accelerate aging in the cochlea, the hearing organ, by increasing oxidative stress, which leads to early signs of age-related hearing loss.

Dec 31, 2025

Gemini

Modulation Of Liquid-To-Solid Phase Transition In Coacervates For Neurodegenerative Disease Treatments

Aging Theory

Aging Pathway

Therapeutic

The paper reviews how the abnormal change of liquid-like cellular compartments into solid structures contributes to neurodegenerative diseases and explores strategies to control this process for potential treatments.

Dec 31, 2025

Gemini

Oral Short-Chain Fatty Acid-Producing Bacteria May Be Associated With Biological Age And Cognition Among The Oldest Old

Analytical

Aging Pathway

The composition of bacteria in the mouth, particularly those producing short-chain fatty acids, is linked to an individual’s biological age and cognitive abilities among the very elderly.

Dec 31, 2025

Gemini

Senescent Cd8 T Effector Memory Cells Are Functionally Impaired, Enriched In Aging And Disease, And A Barrier To Immunotherapy

Aging Theory

Aging Pathway

Therapeutic

Analytical

A specific type of immune cell, called senescent CD8 T effector memory cells, becomes dysfunctional, accumulates with age and disease, and acts as a barrier to effective immunotherapy.

Dec 31, 2025

Gemini

Sex-Specific Association Of Telomere Length With Individualized Expected Years Of Life Lost Among 203,731 Males And 241,668 Females

Aging Theory

Analytical

The relationship between the length of protective caps on chromosomes, called telomeres, and an individual’s expected years of life lost differs significantly between males and females, and also varies in females depending on menopausal status.

Dec 31, 2025

Gemini

The Yin And Yang Of Cellular Senescence In Ischemia-Induced Myocardial Injury

Aging Pathway

Therapeutic

The paper reveals that cellular senescence, a state where cells stop dividing, is induced in heart muscle and other heart cells following ischemia-reperfusion injury, and that removing these senescent cells can improve heart function, increase blood vessel formation, and reduce scar tissue.

Dec 31, 2025

Gemini

Defective RNA Processing And ELOA-Mediated Transcriptional Elongation In Reversible Cellular Senescence Suggest Aging By Transcription

Aging Theory

Aging Pathway

Analytical

Researchers have discovered that errors in how RNA is processed and how genes are copied, specifically involving a protein called ELOA, contribute to cellular aging and a state where cells stop dividing.

Dec 30, 2025

Gemini

Aging Pathway

Analytical

A study of long-lived individuals revealed that not all of them share the same metabolic profile; a distinct subgroup exhibited significant metabolic alterations, including elevated levels of butyric acid derivatives, alongside cardiovascular disease.

Dec 30, 2025

Gemini

The Regenerative Potential Of Young Versus Senescent Rabbit Adipose-Derived Mesenchymal Stem Cells And Their Impact On The Treatment Of Intervertebral Disc Degeneration

Therapeutic

Aging Pathway

Young adipose-derived mesenchymal stem cells show promise for regenerating intervertebral discs, while senescent (aged) cells are ineffective and may even worsen the condition.

Dec 30, 2025

Gemini

Age-Dependent Topoisomerase I Depletion Alters Recruitment Of Rdna Silencing Complexes

Aging Theory

Aging Pathway

The study reveals that the age-related decrease of a protein called topoisomerase I in yeast unexpectedly shortens lifespan when its levels are restored, because its overexpression disrupts crucial silencing complexes at ribosomal DNA.

Dec 29, 2025

Gemini

Aging Pathway

Therapeutic

Naringenin, a compound found in plants, has been found to prevent the aging of bone-forming cells and improve bone structure in conditions mimicking age-related bone loss, acting through a pathway involving estrogen receptors.

Dec 29, 2025

Gemini

Β-Sitosterol Extends Lifespan And Healthspan In Caenorhabditis Elegans Via Multi-Omics Analysis Of Longevity, Neuronal, And Immune Pathways

Therapeutic

Aging Pathway

Analytical

β-Sitosterol, a natural plant compound, has been found to extend both the lifespan and healthspan of the model organism Caenorhabditis elegans by influencing various biological pathways related to aging, nerve function, and immunity.

Dec 29, 2025

Gemini

DNA Methylation Signatures Of Frailty Beyond Age: A Longitudinal Study Of Female And Male Mice

Analytical

Clock

Aging Pathway

A longitudinal study in mice identified specific DNA methylation patterns, or epigenetic signatures, associated with frailty, distinguishing between age-independent and age-dependent mechanisms and revealing potential sex-specific differences.

Dec 28, 2025

Gemini

Food-Derived Antioxidant Peptides Mediated Multifunctional Bioactivities And Bioavailability-Enhancing Delivery Strategies Via The Nrf2/Keap1 Signaling Pathway

Aging Pathway

Therapeutic

Lever

Food-derived antioxidant peptides demonstrate diverse biological activities, including reducing oxidative stress and activating the body’s natural defense mechanisms by influencing the Nrf2/Keap1 signaling pathway.

Dec 28, 2025

Gemini

Hindlimb Unloading Results In Accelerated Bone Loss Compared To Aging In Select Bone Compartments Of Female Murine Femurs

Aging Theory

Hindlimb unloading leads to more rapid bone loss in specific regions of female murine femurs compared to the bone loss associated with natural aging.

Dec 28, 2025

Gemini

Inhibition Of C-Jun/Bak Signaling Alleviates Endothelial Cell Senescence And Inflammation Caused By Mitochondrial Dysfunction In DMED

Aging Pathway

Therapeutic

Analytical

The study revealed that inhibiting c-Jun/Bak signaling can reduce the premature aging and inflammation of endothelial cells, which are often caused by mitochondrial dysfunction in conditions such as diabetic erectile dysfunction.

Dec 28, 2025

Gemini

Neuroinvasion By Simian Immunodeficiency Virus Triggers Glial Senescence And Accelerated Neurodegeneration

Aging Pathway

Simian immunodeficiency virus (SIV) infection in the brain rapidly triggers the premature aging of brain support cells and accelerates brain tissue damage.

Dec 28, 2025

Gemini

The Role Of MICOS In Modulating Mitochondrial Dynamics And Structural Changes In Vulnerable Regions Of Alzheimer’S Disease

Aging Pathway

Therapeutic

Disruption of the mitochondrial contact site and cristae organizing system (MICOS) is a progressive feature of neuronal aging, leading to impaired mitochondrial function and increased vulnerability to Alzheimer’s disease-related neurodegeneration.

Dec 28, 2025

Gemini

Gdf3 Promotes Adipose Tissue Macrophage-Mediated Inflammation Via Altered Chromatin Accessibility During Aging

Aging Pathway

Therapeutic

Analytical

A study reveals that a protein called GDF3 increases with age in fat tissue immune cells, driving inflammation by changing how DNA is accessed, and targeting this pathway could reduce age-related inflammation.

Dec 27, 2025

Gemini

New Perspectives On Gastric Inflammaging: Integrating Multi-Omics Mechanisms And Gerotherapeutic Strategies In Chronic Gastritis

Aging Theory

Aging Pathway

Therapeutic

Lever

Analytical

The paper introduces “gastric inflammaging” as a key mechanism in chronic gastritis, linking age-related inflammation to the progression of gastric mucosal degeneration and cancer, and proposes multi-omics-driven gerotherapeutic strategies.

Dec 27, 2025

Gemini

Senotherapeutics For Brain Aging Management

Aging Pathway

Therapeutic

Senotherapeutics, a class of drugs that target aging cells, show potential in mitigating age-related cognitive decline and promoting healthy brain aging by reducing neuroinflammation and improving brain function.

Dec 27, 2025

Gemini

Aging Theory

Therapeutic

An imbalance in the gut microbiota, known as dysbiosis, is a significant factor in the aging process and contributes to the development of various age-related conditions, including neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes.

Dec 25, 2025

Gemini

Influenza A Infection Accelerates Disease-Associated Microglia Formation During Physiological Aging

Aging Theory

Aging Pathway

Analytical

Influenza A pneumonia accelerates the age-dependent increase of specialized immune cells in the brain, known as disease-associated microglia, particularly in middle-aged individuals.

Dec 25, 2025

Gemini

Pharmacological Activation Of Mitophagy Confers Neuroprotective Benefits For Amyotrophic Lateral Sclerosis

Aging Pathway

Therapeutic

Pharmacological activation of mitophagy, a cellular process that removes damaged mitochondria, shows promise in protecting motor neurons and improving symptoms in models of Amyotrophic Lateral Sclerosis.

Dec 25, 2025

Gemini

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent Β Cells And Cure Age-Related Diabetes In Mice

Aging Theory

Aging Pathway

Therapeutic

Small extracellular vesicles derived from human amniotic membrane mesenchymal stem cells can rejuvenate aged pancreatic beta cells and reverse age-related diabetes in mice.

Dec 25, 2025

Gemini

Aging Pathway

Therapeutic

Hydroxysafflower yellow A protects skin from aging caused by UVA and UVB radiation by preventing cell death and reducing harmful inflammatory responses.

Dec 24, 2025

Gemini

Long-Term High-Protein Diet Intake Accelerates Adipocyte Senescence Through Macrophage Cd38-Mediated NAD⁺ Depletion

Aging Pathway

Therapeutic

Lever

Analytical

Long-term consumption of high-protein diets can accelerate the aging of fat cells by reducing a crucial molecule called NAD+ through the action of immune cells.

Dec 24, 2025

Gemini

PFOS-Induced Black Liver And Hepatic Aging In Mice: A New Paradigm In Environmental Hepatotoxicology

Aging Theory

Aging Pathway

Therapeutic

Chronic exposure to the environmental contaminant PFOS can lead to a distinct “black liver” and signs of accelerated liver aging in mice.

Dec 24, 2025

Gemini

Piezo1 Activation Mediates Stiffness-Induced Aortic Medial Calcification: Pharmacological Evidence From Agonist And Antagonist Studies

Aging Pathway

Therapeutic

The mechanosensitive ion channel Piezo1 is a central mediator in the process where increased arterial stiffness leads to the calcification of blood vessels, making it a potential target for new therapies.

Dec 24, 2025

Gemini

Relationships Among Dietary Patterns And Heterogeneous Biological Aging At System And Organ-Specific Levels And Mortality Risks

Clock

Aging Theory

Aging Pathway

Research investigates how the cellular recycling process, autophagy, is impacted by microgravity in space, using this unique environment as a model to accelerate the study of aging and develop potential interventions for age-related diseases on Earth.

Dec 22, 2025

Gemini

Immunoinformatics-Guided Approach To Target Cisd2 Upregulation Using (2R)-2-[3,4-Bis(Oxidanyl)Phenyl]-6-Oxidanyl-2,3-Dihydrochromen-4-One(6J6) For Treating Chronic Kidney Disease: Enhancing Cisd2 Upregulation To Combat CKD Through 6J6

Aging Pathway

Therapeutic

Analytical

A computational study identified a compound named 6J6 as a promising candidate to enhance the activity of the CISD2 protein, which is crucial for mitochondrial health and cellular longevity, potentially offering a new therapeutic approach for chronic kidney disease.

Dec 22, 2025

Gemini

Methylarginine Levels And Their Impact On Vascular Aging: A Systematic Review

Aging Pathway

Analytical

Elevated levels of specific molecules called methylarginines are associated with the worsening of blood vessel function, increased risk of heart disease, and cognitive decline in older adults.

Dec 22, 2025

Gemini

Sirt3 Deficiency Exacerbates Cognitive Decline By Disrupting Mitochondrial Antioxidant Homeostasis In D-Galactose-Induced Aging Mice

Aging Pathway

Therapeutic

Analytical

A deficiency in the mitochondrial protein SIRT3 worsens age-related cognitive decline by disrupting the balance of protective molecules within the cell’s powerhouses.

Dec 22, 2025

Gemini

Tapioca Starch Nanoparticles Loaded With Astaxanthin Extend The Lifespan Of Caenorhabditis Elegans By Activating DAF-16

Therapeutic

Aging Pathway

Tapioca starch nanoparticles carrying astaxanthin have been shown to extend the lifespan of the nematode Caenorhabditis elegans by activating a key longevity pathway.

Dec 22, 2025

Gemini

Theobromine Is Associated With Slower Epigenetic Ageing

Lever

Analytical

A recent study found that higher levels of theobromine, a compound naturally present in cocoa, are linked to a slower rate of biological aging at the molecular level in humans.

Dec 22, 2025

Gemini

Age- And Cell-Type-Specific Effects Of Histone Variant H2Be In The Brain

Aging Pathway

A specific histone variant, H2BE, accumulates in brain cells with age and plays a crucial role in regulating gene expression and synaptic function, impacting both long-term and working memory in aging mice.

Dec 21, 2025

Aging Pathway

Polyethylene microplastics significantly reduce cell viability, increase reactive oxygen species production, and cause mitochondrial damage in lung epithelial cells and macrophages, ultimately inducing apoptosis and senescence in a dose- and time-dependent manner.

Dec 21, 2025

Gemini

Why We Age

Aging Theory

Aging is best explained by optimization theories, which propose that evolutionary forces actively select for aging due to resource constraints, a perspective supported by various observed aging phenomena.

Dec 21, 2025

Gemini

Comprehensive Transcriptomic Profiling Reveals Lncrna-Mirna-Mrna Regulatory Networks In Skeletal Muscle Aging Of Mice

Aging Pathway

Analytical

This study systematically profiled age-related changes in long non-coding RNAs, microRNAs, and messenger RNAs in mouse skeletal muscle and constructed core regulatory networks to understand their interplay in the aging process.

Dec 20, 2025

Gemini

Decreased Opa1 Expression Increases Neuronal Vulnerability To Ischaemic Stroke During Ageing: Role Of Timm8B As A Therapeutic Target

Clock

Analytical

The study found that while some biological aging clocks are affected by the differences between older and newer DNA methylation arrays, measures of “AgeAcceleration” remain largely consistent and reliable.

Dec 17, 2025

Aging Pathway

Clock

Analytical

A recent study revealed a significant connection between variations in mitochondrial DNA within cells and widespread changes in the methylation patterns of nuclear DNA, suggesting a cellular communication network that influences gene activity.

Dec 16, 2025

Aging Pathway

The paper reveals that the gradual reduction of a protein complex called cohesin in egg cells is a primary reason for the increase in chromosome errors, known as aneuploidy, as females age, contributing to a decline in fertility.

Dec 9, 2025

Gemini

S-Nitrosation In Endothelium: Different Outcomes Of Nrf2 And GSNOR Loss

Aging Pathway

The study reveals that the loss of the protective protein NRF2 in cells lining blood vessels leads to premature aging and increased S-nitrosation, a type of protein modification, while the loss of the enzyme GSNOR, which removes S-nitrosation, does not result in the same aging, highlighting that the context of S-nitrosation is crucial for cell fate.

Dec 9, 2025

Gemini

Therapeutic Targeting Of Lncrnas In Age-Related Ocular Disease

Therapeutic

Long non-coding RNAs (lncRNAs) are emerging as crucial players in age-related eye diseases, offering potential avenues for new diagnostic tools and treatments to prevent or slow vision loss.

Dec 9, 2025

Gemini

Transient Receptor Potential Vanilloid 4 Antagonist Eliminated Age-Related Spatial Memory Deficit In Female Sprague Dawley Rats

Aging Pathway

A study found that blocking a specific protein channel, TRPV4, in the brain can reverse age-related spatial memory problems in female rats.

Dec 9, 2025

Gemini

Adipose Immune Microenvironment: Catalyst Of Age-Related Adipose Tissue Dysfunction

Aging Theory

Aging Pathway

Therapeutic

The immune environment within fat tissue significantly contributes to the development of age-related problems in fat tissue function.

Dec 6, 2025

Gemini

Adrenal Aging: Region-Specific Vulnerability And Proteostatic Decline - Mechanisms, Biomarkers, And Translational Opportunities

Aging Theory

Aging Pathway

Clock

Therapeutic

Analytical

Adrenal gland aging is not uniform across its regions, with specific areas showing greater vulnerability to decline due to issues with protein maintenance and the supply of essential building blocks like cholesterol.

Dec 6, 2025

Gemini

Aging Anxiety And Epigenetic Aging In A National Sample Of Adult Women In The United States

Clock

Analytical

A study found that anxiety about declining health is associated with a faster pace of biological aging in adult women.

Dec 6, 2025

Gemini

AI-Driven Discovery Of Dual Antiaging And Anti-AD Therapeutics Via PROTAC Target Deconvolution Of A Super-Enhancer-Regulated Axis

Therapeutic

Analytical

Aging Pathway

An artificial intelligence-driven approach has identified melatonin as a promising therapeutic candidate with dual anti-aging and anti-Alzheimer’s disease properties.

Dec 6, 2025

Gemini

Aging Pathway

Therapeutic

A compound found in ginseng, Ginsenoside Re, has been shown to protect against age-related brain degeneration by improving the health and function of mitochondria, the powerhouses of cells.

Dec 6, 2025

Gemini

Igf2Bp2-Mediated M6A Modification Of Igf1R Mrna Promotes Neuronal Senescence And Cognitive Decline In Alzheimer’S Disease

Aging Pathway

Therapeutic

A protein called IGF2BP2, by modifying a specific RNA molecule (IGF1R mRNA), promotes the aging of brain cells and contributes to memory loss in Alzheimer’s disease.

Dec 6, 2025

Gemini

LCMV-Mediated Loss Of Virtual Memory Cd8 T Cells Yields A Functionally Enhanced T Cell Subset

Aging Pathway

Exposure to a specific viral infection early in life can lead to a long-lasting reduction in certain immune cells, called virtual memory T cells, but the remaining cells become more responsive and functionally enhanced.

Dec 6, 2025

Gemini

Machine Learning Predicts Lifespan And Suggests Underlying Causes Of Death In Aging C. Elegans

Analytical

Aging Theory

Machine learning can accurately predict the lifespan of C. elegans worms and identify specific organ pathologies, particularly in the pharynx and intestine, as major contributors to their death.

Dec 6, 2025

Gemini

Male Monocyte-Like Cells Are Prone To A Senescence-Induced Pro-Inflammatory State

Aging Theory

Spermine Modulation Of Alzheimer’S Tau And Parkinson’S Α-Synuclein: Implications For Biomolecular Condensation And Neurodegeneration

Aging Pathway

Therapeutic

Spermine, a naturally occurring molecule, has been found to influence the clumping of proteins associated with Alzheimer’s and Parkinson’s diseases, potentially offering a protective mechanism against neurodegeneration.

Dec 6, 2025

Gemini

The Effect Of Epigenetic Age Acceleration On Atopic Dermatitis: A Mendelian Randomization Study

Clock

Analytical

A study found that atopic dermatitis is causally linked to an accelerated biological aging process in the immune system, specifically as measured by the HannumAge epigenetic clock.

Dec 6, 2025

Gemini

The Efficacy Of Longevity Interventions In Caenorhabditis Elegans Is Determined By The Early Life Activity Of RNA Splicing Factors

Aging Theory

Aging Pathway

Therapeutic

Analytical

The effectiveness of treatments designed to extend lifespan in the worm Caenorhabditis elegans is determined by the activity of specific RNA splicing factors during the early stages of its life.

Dec 6, 2025

Gemini

The Muscle-Brain Axis In Type 2 Diabetes: Molecular Pathways Linking Sarcopenia And Cognitive Decline

Aging Pathway

Lever

Type 2 diabetes is increasingly recognized as a shared pathological substrate for both sarcopenia, which is age-related muscle loss, and cognitive decline, including Alzheimer’s disease, with a bidirectional communication network between muscles and the brain playing a central role.

Dec 6, 2025

Gemini

Trigonelline Activates Nrf2 And Awakens Dormant Ovarian Follicles To Promote Pregnancy In Aging Mice

Aging Pathway

Therapeutic

A natural compound called trigonelline activates a protective pathway in cells, leading to the awakening of dormant egg cells and improved pregnancy outcomes in older mice.

Dec 6, 2025

Gemini

Vitamin C As An Epigenetic Gatekeeper Of Osteogenesis And Skeletal Health - A New Perspective On An Ancient Molecule

Aging Pathway

Therapeutic

Lever

Recent research indicates that Vitamin C plays a crucial role in regulating gene expression, acting as an epigenetic controller that directly influences bone formation and overall skeletal health, expanding its known functions beyond collagen synthesis.

Dec 6, 2025

Gemini

A Collagen Amino Acid Composition Supplementation Reduces Biological Age In Humans And Increases Health And Lifespan In Vivo

Therapeutic

Clock

A specific combination of amino acids, the building blocks of collagen, has been found to reduce biological age in humans, improve skin health, and extend health and lifespan in animal models.

Dec 5, 2025

Gemini

A Smoothing Method For DNA Methylome Analysis To Enhance Epigenomic Signature Detection In Epigenome-Wide Association Studies

Analytical

Clock

A new smoothing method improves the ability of epigenome-wide association studies to detect meaningful DNA methylation changes linked to human traits and diseases, even in studies with small numbers of participants.

Dec 5, 2025

Gemini

Aging Pathway

Inhibition of a cellular recycling process called autophagy in intestinal stem cells leads to an increase in specialized gut cells responsible for hormone production, a process regulated by the Stat92E signaling pathway.

Dec 5, 2025

Gemini

Combined Association Between Phenotypic Age Acceleration And Dietary Fiber Intake With Mortality In Middle-Aged And Elderly Cancer Survivors

Clock

Lever

Analytical

Accelerated biological aging and lower dietary fiber intake are independently associated with increased mortality in middle-aged and elderly cancer survivors, with a significant combined effect on cancer mortality.

Dec 5, 2025

Gemini

Combined Protection Against UVB-Induced Photoaging By Oleuropein, Hydroxytyrosol, And Verbascoside Through Modulation Of Inflammation, Oxidative Stress, And Collagen Homeostasis

Therapeutic

Aging Pathway

A combination of oleuropein, hydroxytyrosol, and verbascoside, derived from olive leaves, offers protection against skin aging caused by UVB radiation by reducing inflammation, oxidative stress, and the breakdown of collagen.

Dec 5, 2025

Gemini

[Effect And Mechanism Of Astaxanthin On The Aging Of High Glucose-Treated Human Skin Fibroblasts]

Therapeutic

Aging Pathway

Astaxanthin can reduce the aging of human skin cells caused by high sugar levels by decreasing oxidative stress and activating a protective cellular pathway.

Dec 5, 2025

Gemini

Effects Of Two Longevity Interventions, Calorie Restriction And Rapamycin Treatment, On The Kynurenine-Aryl Hydrocarbon Receptor Pathway In Aging Skeletal Muscle

Aging Pathway

Therapeutic

Lever

Analytical

Calorie restriction and rapamycin treatment, while both beneficial for aging muscles, achieve their positive effects through distinct molecular pathways rather than identical mechanisms.

Dec 5, 2025

Gemini

Endothelial Senescent-Cell-Specific Clearance Alleviates Metabolic Dysfunction In Obese Mice

Aging Pathway

Therapeutic

Researchers found that specifically removing aged blood vessel cells in obese mice reduced inflammation and fat mass, and improved blood sugar levels.

Dec 5, 2025

Gemini

Exploring Potential Associations Between HIV Acquisition And Biological Aging: Insights From A Bidirectional Mendelian Randomization Study

Analytical

Clock

A study using genetic data found no significant causal link between acquiring HIV and biological aging, nor did biological aging causally influence HIV acquisition.

Dec 5, 2025

Gemini

From Senescent Cells To Systemic Inflammation: The Role Of Inflammaging In Age-Related Diseases And Kidney Dysfunction

Aging Theory

Aging Pathway

Aging Pathway

Researchers have discovered a common trigger for the cellular process that removes damaged mitochondria, finding that various types of mitochondrial damage all lead to a loss of mitochondrial membrane potential, which then activates the PINK1-Parkin pathway to initiate the removal process.

Dec 4, 2025

Gemini

Age-Associated G-Quadruplex Accumulation And Ddx5 Loss Shape Chromatin Landscapes In Human Astrocytes

Aging Theory

Aging Pathway

Analytical

As human astrocytes age, there is an increase in G-quadruplex structures and a decrease in the DDX5 protein, which together alter the organization of the cell’s genetic material.

Dec 4, 2025

Gemini

Aging Pathway

Therapeutic

Lever

Analytical

Calorie restriction, but not rapamycin treatment, significantly altered the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle, suggesting distinct mechanisms for these longevity interventions.

Dec 4, 2025

Gemini

Endothelial Senescent-Cell-Specific Clearance Alleviates Metabolic Dysfunction In Obese Mice

Aging Pathway

Therapeutic

Targeted removal of aged cells lining blood vessels in obese mice significantly reduced inflammation and improved their metabolic health, including better blood sugar control.

Dec 4, 2025

Gemini

Exploring Potential Associations Between HIV Acquisition And Biological Aging: Insights From A Bidirectional Mendelian Randomization Study

Clock

Analytical

A study using genetic data found no significant causal link between genetically predicted HIV acquisition and biological aging, nor between biological aging and HIV acquisition.

Dec 4, 2025

Gemini

From Senescent Cells To Systemic Inflammation: The Role Of Inflammaging In Age-Related Diseases And Kidney Dysfunction

Aging Theory

Aging Pathway

Therapeutic

Lever

Aging is characterized by a chronic, low-grade inflammatory state, termed inflammaging, which is driven by the accumulation of senescent cells and their inflammatory secretions, contributing to various age-related diseases, including kidney dysfunction.

Dec 4, 2025

Gemini

FTO Suppresses Dental Pulp Stem Cell Senescence By Destabilizing Nolc1 Mrna

Aging Pathway

Therapeutic

The protein FTO prevents the aging of dental pulp stem cells by destabilizing NOLC1 messenger RNA, which otherwise promotes cellular aging.

Dec 4, 2025

Gemini

Hepatocyte Mitochondrial NAD⁺ Content Is Limiting For Liver Regeneration

Aging Pathway

Therapeutic

The amount of NAD+ within the mitochondria of liver cells directly controls how quickly the liver can regenerate.

Dec 4, 2025

Gemini

Therapeutic

Aging Pathway

A natural compound called (+)-epicatechin was found to improve both short-term and long-term memory in aged rats by enhancing brain cell function, reducing harmful stress, and lowering inflammation.

Dec 4, 2025

Therapeutic

Aging Pathway

A recent study found that the drug Edaravone can protect nerve cells from premature aging by reducing cellular damage and regulating genes associated with the aging process.

Dec 3, 2025

Gemini

Electron Microscopy And Multi-Omics Reveal Mitochondrial Dysfunction And Structural Remodeling In The Hearts Of Elderly Mice

Aging Pathway

Analytical

A study using advanced imaging and molecular techniques revealed that the hearts of elderly mice exhibit enlarged and structurally damaged mitochondria, alongside significant alterations in gene expression, protein function, and metabolism.

Dec 3, 2025

Gemini

Epigenetic Age Predicts Depressive Symptoms During The COVID-19 Pandemic In The Canadian Longitudinal Study On Aging: Importance Of Biological Sex

Clock

Analytical

A study found that younger biological age, as measured by epigenetic markers, predicted an increase in depressive symptoms among females during the early stages of the COVID-19 pandemic.

Dec 3, 2025

Gemini

Glycemic Status-Dependent Proteomic Signatures Of Biological Aging For Health Risk Prediction

Clock

Analytical

The study found that protein-based aging scores, specifically tailored to an individual’s blood sugar status, can more accurately predict the risk of death and age-related diseases than general aging measures.

Dec 3, 2025

Gemini

N-Butanol Fraction Of Ligustrum Lucidum Benefits Muscular Function And Myofibers Of Aging Ovariectomized Mice And Rats By Retarding Senescence-Related Events In Skeletal Muscle

Therapeutic

Aging Pathway

Aging Theory

A specific extract from the traditional Chinese herb Fructus Ligustri Lucidi has been shown to improve muscle mass, strength, and the health of muscle fibers in aging animal models that mimic post-menopausal conditions.

Dec 3, 2025

Gemini

Immunoglobulin G And Aging: Biological Functions And Its Crosstalk With The Gut Microbiota

Aging Theory

Aging Pathway

Clock

Therapeutic

Immunoglobulin G, a key immune molecule, undergoes structural changes with age that promote inflammation and contribute to age-related diseases, with its function closely intertwined with the gut microbiota.

Dec 3, 2025

Gemini

Machine-Learning Models Based On Histological Images From Healthy Donors Identify Imageqtls And Predict Chronological Age

Clock

Analytical

Machine learning models can analyze microscopic images of healthy human tissues to identify genetic factors that influence tissue appearance and accurately predict a person’s chronological age.

Dec 3, 2025

Gemini

Mechanisms Of Transcription-Coupled Repair And DNA Damage Surveillance In Health And Disease

Aging Theory

Aging Pathway

Cells possess specialized mechanisms to detect and repair DNA damage that obstructs gene transcription, preventing cellular dysfunction, neurodegeneration, and aging.

Dec 3, 2025

Gemini

Clock

Analytical

A higher C-reactive protein-albumin-lymphocyte (CALLY) index is associated with a lower risk of death from all causes and cardiovascular disease in people with chronic kidney disease, with biological age acceleration partially explaining this relationship.

Dec 3, 2025

Gemini

Persistent Oxidation Of Mitochondrial And Transmembrane Proteins In Rat Cerebrum And Heart Regardless Of Age Or Nutrition

Aging Theory

Aging Pathway

Lever

Analytical

A study found that a significant number of mitochondrial and transmembrane proteins in rat brains and hearts remain highly oxidized regardless of the animal’s age or diet, yet their function is maintained.

Dec 3, 2025

Gemini

Piracetam Attenuates Oxidative Stress And Inflammation-Induced Neuronal Cell Death In Rats With Vascular Dementia Potentially Via The Activation Of The AMPK/SIRT-1/Nrf-2 Signaling Pathway

Therapeutic

Aging Pathway

Piracetam was found to reduce brain cell death caused by oxidative stress and inflammation in rats with vascular dementia by activating specific signaling pathways, leading to improved cognitive performance.

Dec 3, 2025

Gemini

RE-Aging, A Functional Analysis Platform For Human RNA Editing Associated With Aging

Analytical

Aging Pathway

Clock

A new platform has been developed to systematically analyze how RNA editing, a process that modifies genetic messages, changes in human tissues as people age.

Dec 3, 2025

Gemini

Ribosome Dysregulation And Intervention In Age-Related Infertility

Aging Pathway

Therapeutic

Research has identified that increased activity of ribosome genes in egg cells and surrounding support cells contributes to age-related infertility, and a drug called rapamycin shows promise in improving fertility outcomes.

Dec 3, 2025

Gemini

Scgenebank: Cross-Species Screening Of Functional Gene Sets At Single-Cell Resolution

Analytical

A new database and analysis tool has been developed to allow researchers to explore how groups of genes function across different species, organs, and cell types at a very detailed level.

Dec 3, 2025

Gemini

Aging Pathway

Therapeutic

Analytical

The study identified new markers of Alzheimer’s disease pathology driven by tau protein and revealed how tau alterations affect communication between brain cells and the breakdown of connections between neurons.

Dec 2, 2025

Gemini

Loss Of Bap31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration

Aging Pathway

Analytical

The absence of the protein BAP31 in photoreceptor cells contributes to age-related retinal degeneration by triggering stress in the endoplasmic reticulum.

Dec 2, 2025

Gemini

Not All Saliva Samples Are Equal: The Role Of Cellular Heterogeneity In DNA Methylation And Epigenetic Age Analyses With Biological And Psychosocial Factors

Clock

Analytical

The cellular composition of saliva samples significantly impacts DNA methylation and epigenetic age analyses, with child-specific cell type reference panels proving more accurate for pediatric studies and immune cell-rich samples showing stronger associations with environmental exposures like tobacco smoke.

Dec 2, 2025

Gemini

Polycomb Misregulation In Enterocytes Drives Tissue Decline In The Aging Drosophila Intestine

Aging Theory

Aging Pathway

Analytical

Aging causes a specific gene regulation system in gut cells to malfunction, leading to a decline in tissue function and showing similarities to changes observed in cancer.

Dec 2, 2025

Gemini

Aging Theory

Aging Pathway

Activation of a specific cellular signaling pathway, called cGAS-STING, in aging cells contributes to the aging process by changing how the immune system functions.

Nov 30, 2025

Gemini

Autophagic Failure With Age: Influence On Metabolic Disorders And Prospects For Therapeutic Targeting

Aging Pathway

Therapeutic

Analytical

The age-related decline in the cellular recycling process called autophagy contributes to metabolic disorders and represents a promising target for new therapies.

Nov 30, 2025

Gemini

Long-Term Senolytic Treatment Prevents Endothelial Dysfunction In Arterial Aging

Therapeutic

Aging Pathway

Long-term treatment with drugs that clear senescent cells can prevent the decline in blood vessel function associated with aging.

Nov 30, 2025

Gemini

Ovarian Aging: Mechanisms, Age-Related Disorders, And Therapeutic Interventions

Aging Theory

Aging Pathway

Therapeutic

Analytical

A study using genetic data has identified specific types of immune cells that can causally influence the speed at which a person biologically ages, suggesting potential targets for interventions to slow down aging.

Nov 29, 2025

Gemini

Control Of Aging-Associated Neurodegeneration Via Hypothalamic Extracellular Vesicles Containing Parathymosin

Aging Pathway

Therapeutic

A recent study reveals that a protein called parathymosin, delivered by tiny cellular packages from the hypothalamus, plays a crucial role in protecting brain cells from age-related damage and can extend lifespan.

Nov 29, 2025

Gemini

Deciphering The Nexus Of Aging And Pan-Cancer: Single-Cell Sequencing Reveals Microenvironmental Remodeling And Cellular Drivers

Aging Theory

Aging Pathway

Analytical

Therapeutic

Aging significantly contributes to cancer development by altering the tumor microenvironment through the accumulation of senescent cells and the weakening of anti-tumor immunity.

Nov 29, 2025

Gemini

Aging Pathway

Analytical

The study identified specific gene regulatory networks and transcription factors that are disrupted with age, contributing to the reduced ability of the central nervous system to repair myelin, a process crucial for neurological function and often impaired in diseases like multiple sclerosis.

Nov 29, 2025

Gemini

Enhancer Rewiring Orchestrates Inflammation And Loss Of Cell Identity During Muscle Stem Cell Aging

Aging Theory

Aging Pathway

Analytical

During aging, muscle stem cells experience changes in their genetic regulation, leading to increased inflammation and a loss of their specialized identity, which impairs the muscle’s ability to regenerate.

Nov 29, 2025

Gemini

Fibroblast Growth Factor Signaling Induces A Chondrocyte-Like State Of Peripheral Nerve Fibroblast During Aging

Aging Pathway

Analytical

Therapeutic

A recent study found that increased signaling from fibroblast growth factors, originating from fat cells, causes peripheral nerve fibroblasts to adopt a cartilage-like state during aging, contributing to age-related nerve changes.

Nov 29, 2025

Gemini

Immune Age, Cardiovascular Disease, And Anti-Viral Immunity

Aging Theory

Aging Pathway

Aging of the immune system, characterized by declining immune function and chronic inflammation, contributes to both increased susceptibility to severe viral infections and the development of cardiovascular diseases.

Nov 29, 2025

Gemini

Interleukin-17F Induces Ischemic Injury In Aged Mice By Causing Endothelial Cells’ Senescence And Dysfunction

Aging Pathway

Therapeutic

Elevated levels of Interleukin-17F are linked to increased severity of peripheral arterial disease and cardiovascular issues in older individuals, by causing premature aging and impaired function of blood vessel lining cells.

Nov 29, 2025

Gemini

Losing The Filter: How Kynurenine Pathway Dysregulation Impairs Habituation

Aging Theory

Aging Pathway

Therapeutic

Dysregulation of the kynurenine pathway, particularly through the enzyme KMO, is a key driver of age-related deficits in habituation, and inhibiting KMO can help preserve this cognitive function.

Nov 29, 2025

Gemini

Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment In Mesenchymal Stem Cells Via Cxcr4/Pi3K/AKT Signaling

Aging Pathway

Lever

Mechanical stretch can prevent the age-related decline in the ability of stem cells to form new bone by activating a specific cellular pathway.

Nov 29, 2025

Gemini

Metabolomic Investigation Of Myelodysplastic Syndromes, Multiple Myeloma, And Homozygous Β-Thalassemia

Aging Pathway

Therapeutic

This review summarizes current knowledge on metabolic changes in myelodysplastic syndromes, multiple myeloma, and homozygous β-thalassemia, identifying potential new targets for treatment.

Nov 29, 2025

Gemini

Methylglyoxal-Induced Glycation Stress Promotes Aortic Stiffening: Putative Mechanistic Roles Of Oxidative Stress And Cellular Senescence

Aging Theory

Aging Pathway

Therapeutic

Analytical

Methylglyoxal-induced glycation stress directly contributes to aortic stiffening by promoting oxidative stress and cellular senescence, and these effects can be mitigated by a glycation stress-lowering compound.

Nov 29, 2025

Gemini

Oocyte Age-Dependent DNA Damage Can Be Reverted By The DNA Repair Competent Karyoplasm Of Young Oocytes

Aging Theory

Aging Pathway

Therapeutic

Age-related DNA damage in oocytes, previously considered irreversible, can be significantly reduced and partially reversed by transferring the nucleus of an older oocyte into the cytoplasm of a younger oocyte.

Nov 29, 2025

Gemini

Phenotypic And Metabonomics Studies Of Fmos In C. Elegans And Their Roles In Lifespan Extension

Aging Pathway

Analytical

Genetic modifications affecting Flavin-Containing Monooxygenases (FMOs) in C. elegans, specifically the loss of fmo-4 and fmo-3 or overexpression of fmo-2, resulted in elevated tryptophan levels and an extended lifespan.

Nov 29, 2025

Gemini

Regional Brain Aging Patterns Reveal Disease-Specific Pathways Of Neurodegeneration

Clock

Analytical

A new deep learning framework can create detailed maps of brain aging, revealing specific patterns of accelerated aging linked to different neurodegenerative diseases like Alzheimer’s, frontotemporal dementia, and schizophrenia.

Nov 29, 2025

Gemini

Rutin As A Circadian Modulator Preserves Skeletal Muscle Mitochondrial Function And Reduces Oxidative Stress To Protect Against D-Galactose-Induced Aging In Vitro And In Vivo

Therapeutic

Aging Pathway

Rutin, a natural compound, has been found to protect against skeletal muscle aging by improving the body’s internal clock, reducing cellular damage, and enhancing the function of energy-producing parts within muscle cells.

Nov 29, 2025

Aging Theory

Aging Pathway

Aging of the immune system contributes to both increased risk of cardiovascular disease and a reduced ability to fight off viral infections through shared underlying mechanisms.

Nov 28, 2025

Gemini

Losing The Filter: How Kynurenine Pathway Dysregulation Impairs Habituation

Aging Theory

Aging Pathway

Therapeutic

Dysregulation of the kynurenine pathway, particularly through the enzyme KMO, drives age-related declines in habituation by promoting neurotoxic processes, and inhibiting KMO can preserve this fundamental learning ability in older mice.

Nov 28, 2025

Gemini

Clock

Analytical

A new deep learning framework, BrainAgeMap, generates detailed maps of brain aging to reveal specific patterns of accelerated aging linked to various neurodegenerative and psychiatric disorders.

Nov 28, 2025

Aging Pathway

Therapeutic

A peptide called Acein has been found to reduce skin damage and aging caused by ultraviolet (UV) radiation by targeting a specific protein and decreasing a factor associated with aging.

Nov 27, 2025

Gemini

Association Between Cd4+/PD-1+/Cd153+ Cell Infiltration To The Aging Liver And Progression Of Hepatic Steatosis In A Novel MASH Model NI Mouse

Aging Theory

Aging Pathway

A study identified a link between the infiltration of specific immune cells, called CD4+/PD-1+/CD153+ cells, into the aging liver and the worsening of fat accumulation in a new mouse model of metabolic disorder-associated steatohepatitis.

Nov 27, 2025

Gemini

Aging Pathway

Sirtuins As Therapeutic Targets For Treating Cancer, Metabolic Diseases, And Neurodegenerative Diseases

Aging Pathway

Therapeutic

Sirtuins, a family of enzymes, are emerging as promising targets for developing new treatments for a range of conditions including cancer, metabolic disorders, and neurodegenerative diseases due to their diverse roles in cellular health and disease progression.

Nov 27, 2025

Gemini

Therapeutic

Aging Pathway

Analytical

Small vesicles released by induced pluripotent stem cells can reverse the aging of natural killer immune cells and enhance their ability to fight tumors by targeting a specific cellular pathway.

Nov 26, 2025

Gemini

Mitochondrial Sirtuins Sir-2.2 And Sir-2.3 Regulate Lifespan In C. Elegans

Aging Pathway

Aging Theory

A study revealed that removing the activity of mitochondrial sirtuins sir-2.2 or sir-2.3 in C. elegans worms can extend their lifespan by over 25%.

Nov 26, 2025

Gemini

Pim1 Induces Hypoxia-Related Fibroblast Senescence In A Mouse Model Of Stress Urinary Incontinence

Aging Pathway

Therapeutic

The protein PIM1 is a key factor linking low oxygen conditions to cellular aging in fibroblasts, which contributes to stress urinary incontinence in a mouse model, and inhibiting PIM1 shows promise as a treatment.

Nov 26, 2025

Gemini

PKA Prevents The Resection Of DNA Double-Strand Breaks And Favours Nonhomologous End-Joining

Aging Theory

Aging Pathway

A protein called PKA helps cells repair broken DNA by promoting a specific repair pathway that directly joins the broken ends, preventing the DNA from being trimmed back.

Nov 26, 2025

Gemini

Aging Theory

Therapeutic

As people age, their immune system naturally weakens, making them more susceptible to infections and reducing the effectiveness of vaccinations.

Nov 25, 2025

Gemini

Association Between Inflammatory Dietary Pattern And Cardiovascular-Kidney-Metabolic Syndrome: A Population-Based Study

Clock

Lever

Analytical

Consuming a diet that promotes inflammation is linked to an increased risk and progression of cardiovascular-kidney-metabolic syndrome, with biological age acceleration playing a mediating role.

Nov 25, 2025

Gemini

Association Of Total Fish-Shellfish Consumption With Biological Aging: A Cross-Sectional Analysis Of NHANES 1999-2020 With Mediation By Inflammatory And Antioxidant Biomarkers

Lever

Mir-133B-3P Mitigates D-Galactose-Induced Hippocampal Neuron Aging Through Autophagy Regulation Via The MAPK/ERK Signaling Pathway

Aging Pathway

Therapeutic

A specific microRNA, miR-133b-3p, helps protect brain cells in the hippocampus from aging by regulating a cellular recycling process called autophagy through a signaling pathway known as MAPK/ERK.

Nov 25, 2025

Gemini

Mirna Changes With Ageing And Caloric Restriction In Male Rat Skeletal Muscle: Potential Roles In Muscle Cell Function

Aging Pathway

Lever

Analytical

Ageing significantly alters the expression of numerous microRNAs in male rat skeletal muscle, and caloric restriction can normalize a substantial portion of these changes, influencing muscle cell function.

Nov 25, 2025

Gemini

Mutation In IR Or Igf1R Produces Features Of Long-Lived Mice While Maintaining Metabolic Health

Aging Pathway

Therapeutic

A specific genetic modification in insulin or IGF-1 receptors in mice promotes characteristics of extended lifespan and healthy metabolism without negative side effects on growth or reproduction.

Nov 25, 2025

Gemini

Pcbp2 Regulates P16^Ink4A-Dependent Cellular Senescence In Response To Iron

Aging Pathway

Therapeutic

A recent study reveals that a protein called PCBP2 controls how cells age and stop dividing, a process known as cellular senescence, in response to iron levels in the body, suggesting a link between iron and age-related diseases like atherosclerosis.

Nov 25, 2025

Gemini

Clock

Lever

Analytical

Exposure to stressful environments during childhood and adolescence is associated with a faster rate of biological aging in young adulthood, and this early-life stress contributes to observed racial differences in aging.

Nov 24, 2025

Gemini

Inferring Pathway Activity From Single-Cell And Spatial Transcriptomics Data With Paasc

Analytical

A new computational method accurately infers the activity of biological pathways from single-cell and spatial gene expression data, outperforming existing tools in various applications and across different data types.

Nov 24, 2025

Gemini

Iron-Deplete Diet Enhances Caenorhabditis Elegans Lifespan Via Oxidative Stress Response Pathways

Aging Pathway

Lever

An iron-depleted diet extends the lifespan of the roundworm Caenorhabditis elegans by activating specific cellular stress response pathways.

Nov 24, 2025

Gemini

Long-Term Exposure To Ultrafine Particles Accelerates Biological Aging And Increases Respiratory Vulnerability In COPD

Clock

Lever

Analytical

Long-term exposure to ultrafine particles accelerates biological aging and worsens respiratory function in individuals with Chronic Obstructive Pulmonary Disease.

Nov 24, 2025

Gemini

Meiotic Cohesion Requires Sirt1 And Preserving Its Activity In Aging Oocytes Reduces Missegregation

Aging Pathway

Therapeutic

The protein Sirt1 is essential for proper chromosome separation during egg cell division, and maintaining its activity in older egg cells can reduce errors that lead to developmental problems.

Nov 24, 2025

Gemini

Profilin 1 Controls A Microglial Cytoskeleton Checkpoint To Prevent Senescence And Premature Synaptic Decline

Aging Pathway

Therapeutic

A protein called Profilin 1 acts as a crucial control point in brain immune cells, preventing them from aging prematurely and protecting connections between brain cells from declining.

Nov 24, 2025

Gemini

Unveiling Nutraceuticals That Modulate Aging Mechanism: Exploring The Intricate Pathways Of Epigenetics

Aging Pathway

Lever

The paper investigates how specific nutrients, known as nutraceuticals, can influence the body’s aging process by modifying epigenetic mechanisms, which are changes in gene activity without altering the DNA sequence itself.

Nov 24, 2025

Gemini

A Proposed Path To Explaining The Unexplained Anemia Of Aging

Aging Theory

Aging Pathway

Analytical

The paper proposes a framework for understanding the various contributing factors to unexplained anemia in older adults, aiming to move beyond a diagnosis of exclusion to identify specific mechanisms and potential interventions.

Nov 23, 2025

Gemini

Integrative Epidemiological And Spatial Multi-Omics Analyses Reveal Spp1⁺ Macrophages With Senescence-Like Features As Key Mediators Linking No₂ Exposure To Coronary Heart Disease

Aging Pathway

Clock

Lever

Analytical

Exposure to nitrogen dioxide, a common air pollutant, is linked to an increased risk of coronary heart disease through its effect on specific immune cells called SPP1⁺ macrophages, which exhibit features of cellular aging.

Nov 23, 2025

Gemini

Aging Pathway

Therapeutic

Activation of the protein Pgk1 can restore the normal metabolic balance in the lining of blood vessels, thereby reducing the effects of vascular aging and the development of atherosclerosis.

Nov 22, 2025

Gemini

Plasma Fatty Acids And The Likelihood Of Healthy Aging: A Prospective Cohort Study

Lever

Analytical

Clock

Higher levels of certain beneficial fats in the bloodstream are associated with a greater likelihood of aging healthily.

Nov 22, 2025

Gemini

Lever

Analytical

A study found that greater muscle mass and strength are associated with a slower biological aging process in middle-aged and older adults.

Nov 21, 2025

Gemini

Association Of Telomere Shortening With Low Back Pain And The Potential Mediating Role Of Smoking: A Cross-Sectional Study

Aging Theory

Aging Theory

Aging Pathway

Therapeutic

The senescence-associated secretory phenotype (SASP) plays a complex, dual role in cancer therapy, initially suppressing tumors but potentially promoting their growth, spread, and resistance to treatment over time.

Nov 21, 2025

Gemini

Tmtcrunch: A Proteomic Atlas Of Alternative Splicing For Predicting Splicing-Induced Implications In Aging And Alzheimer’S Disease

Analytical

Aging Pathway

Researchers developed a new computational tool to create the first comprehensive map of alternatively spliced proteins in Alzheimer’s disease, revealing numerous previously uncharacterized protein forms.

Nov 21, 2025

Gemini

Vascular Niches Are The Primary Hotspots In Cardiac Aging

Aging Pathway

Therapeutic

Analytical

The areas around blood vessels in the heart, known as vascular niches, are identified as the primary locations where age-related damage, inflammation, and scarring accumulate, rather than the heart muscle cells themselves.

Nov 21, 2025

Gemini

Associations Of Outdoor Artificial Light At Night Exposure With Telomere Length And Mitochondrial DNA Copy Number In Children And Adolescents: Examining Sex-Specific Associations

Lever

Analytical

Exposure to outdoor artificial light at night is associated with shorter telomere length in children and adolescents, with a more pronounced effect observed in boys, while no significant association was found with mitochondrial DNA copy number.

Nov 20, 2025

Clock

Analytical

A new imaging technique uses specialized fluorescent dyes to visually measure aging and cellular senescence in living systems in real-time, from individual cells to whole organisms.

Nov 20, 2025

Gemini

Β-Galactosidase-Targeted Senolytic Prodrug Ameliorates Preclinical Models Of Post-Traumatic Osteoarthritis

Aging Pathway

Therapeutic

A new prodrug, SSK1, effectively and precisely eliminates senescent cells, often called “zombie cells,” in models of post-traumatic osteoarthritis, leading to reduced pain and improved joint health.

Nov 20, 2025

Gemini

Metabolic Environment-Driven Remodeling Of Mitochondrial Ribosomes Regulates Translation And Biogenesis

Aging Pathway

The metabolic state of a cell can change the structure and composition of mitochondrial ribosomes, which then adjusts their protein-making activity to match the cell’s energy needs and influences the creation of new mitochondria.

Nov 20, 2025

Gemini

Mitochondrial Metabolism Influences Meiotic Maturation In Human Oocytes Of Young And Advanced Maternal Age Women

Aging Theory

Aging Pathway

Analytical

Poor mitochondrial metabolism hinders the maturation of human oocytes, leading to a reduced capacity for oocyte development in women of advanced maternal age.

Nov 20, 2025

Gemini

Aging Pathway

Lever

Analytical

Unhealthy eating patterns, particularly those high in ultra-processed foods, fats, and sugars, contribute to obesity and metabolic dysfunction, which in turn negatively impact brain health and accelerate cognitive aging through various metabolic, epigenetic, and DNA-repair mechanisms.

Nov 20, 2025

Gemini

Accelerated Biological Aging And Its Hallmarks In DNA Methylation Drive The Association Between Unhealthy Lifestyles And The Onset Of Colorectal Cancer

Clock

Analytical

Aging Theory

Aging Pathway

Clock

Therapeutic

Research indicates that telomere biology plays a significant role in the aging process and the development of various neurological disorders, with telomere shortening potentially contributing to neurodegeneration, immune system aging, and cerebrovascular issues.

Nov 19, 2025

Gemini

Long-Term Exposure To Traffic-Related Air Pollution Is Associated With Epigenetic Age Acceleration

Clock

Lever

Analytical

Long-term exposure to air pollution from traffic is associated with an accelerated biological aging process, particularly in individuals who have previously smoked.

Nov 19, 2025

Gemini

Microvascular Health As A Key Determinant Of Organismal Aging

Aging Theory

Therapeutic

Lever

Analytical

The health of the body’s smallest blood vessels is a crucial factor determining how an organism ages and its susceptibility to age-related diseases.

Nov 19, 2025

Gemini

Role And Mechanisms Of Plant Polyphenols In Ovarian Aging

Aging Theory

Aging Pathway

Therapeutic

Plant polyphenols demonstrate potential in delaying ovarian aging by mitigating oxidative stress, inflammation, and hormonal imbalances, while also positively influencing gut microbiota.

Nov 19, 2025

Gemini

Sulfur Amino Acids, Metabolic Health And Beyond: Recent Advances, Translational Implications, And Future Research Considerations

Aging Pathway

Lever

Dietary restriction of sulfur amino acids, specifically methionine and cysteine, has been shown to delay disease onset and the aging process, and improve metabolic health in various experimental models.

Nov 19, 2025

Gemini

The Bud31 Homologous Gene In Schizosaccharomyces Pombe Is Evolutionarily Conserved And Can Be Linked To Cellular Processes Regulated By The TOR Pathway

Aging Pathway

Analytical

The BUD31 homologous gene in fission yeast, Schizosaccharomyces pombe, is evolutionarily conserved and plays a role in cellular processes regulated by the TOR pathway, offering insights into human diseases like cancer.

Nov 19, 2025

Gemini

Aging Pathway

A recent study reveals that the enzyme Arginase 2 contributes to heart aging through both direct actions within specific heart cells and indirect communication between different cell types in the heart.

Nov 18, 2025

Gemini

Diminished Ceacam1 Level Plays A Critical Role In Age-Related Hepatic Fibrosis

Aging Pathway

Therapeutic

Reduced levels of a protein called CEACAM1 are a key factor in the development of age-related liver scarring.

Nov 18, 2025

Gemini

Herbacetin And Gossypetin Glycosides From Sedum Kamtschaticum Fisch. & C. A. Mey. And S. Takesimense Nakai, And Their Antioxidant, Anti-Aging, And Monoamine Oxidase Inhibitory Activities

Therapeutic

Compounds isolated from Sedum kamtschaticum and Sedum takesimense plants, specifically gossypetin and herbacetin, demonstrated significant antioxidant, anti-aging, and selective monoamine oxidase-B inhibitory activities.

Nov 18, 2025

Gemini

Induced Pluripotent Stem Cell-Derived Extracellular Vesicles Prevent Neural Stem Cell Senescence To Promote Cognitive Recovery After Traumatic Brain Injury

Aging Pathway

Therapeutic

Induced pluripotent stem cell-derived extracellular vesicles have been shown to prevent the aging of neural stem cells and improve cognitive function following traumatic brain injury.

Nov 18, 2025

Gemini

Ketone Catabolism Is Essential For Maintaining Normal Heart Function During Aging

Aging Pathway

Targeting Lysosomal Acidification To Restore Microglial Homeostasis And Mitigate Memory Decline During Male Brain Ageing

Aging Pathway

Therapeutic

A common antihistamine, ketotifen, was found to restore the acidity of cellular waste-disposal units in the brains of aged male mice, leading to healthier brain immune cells, reduced inflammation, and improved memory.

Nov 18, 2025

Gemini

The Energy Resistance Principle

Aging Theory

Lever

The Energy Resistance Principle proposes that life requires a balanced level of energy resistance to transform energy from food into useful work, with imbalances leading to disease and aging.

Nov 18, 2025

Gemini

The Roles Of Eda2R In Ageing And Disease

Aging Theory

Aging Pathway

Clock

Therapeutic

Lever

A recent study identifies the ectodysplasin A2 receptor (EDA2R) as a key regulator and biomarker of aging, demonstrating that its increased expression with age actively promotes inflammation and tissue damage, while its inhibition can lessen these effects.

Nov 18, 2025

Gemini

Transcriptomic Analysis Of Mitohormesis Associated With Lifespan Extension In Caenorhabditis Elegans

Aging Theory

Aging Pathway

Analytical

The study investigated the complex molecular regulation of longevity in the nematode Caenorhabditis elegans under various mitochondrial stressors to determine if specific transcriptomic changes correlate with lifespan extension and the mitochondrial unfolded protein response.

Nov 18, 2025

Gemini

Vitamin D And The Aging Skin: Insights Into Oxidative Stress, Inflammation, And Barrier Function

Aging Theory

Aging Pathway

Therapeutic

Lever

Vitamin D plays a crucial role in combating skin aging by reducing oxidative stress, controlling inflammation, and maintaining the skin’s protective barrier function.

Nov 18, 2025

Gemini

Slowing Down To Take It In: Endocytosis During Cellular Aging

Aging Theory

Aging Pathway

Research indicates that as cells age, an increase in the alkalinity of their internal waste-processing compartments leads to a slowdown in how they absorb materials from their surroundings.

Nov 17, 2025

Gemini

Therapeutic Effect Of A Recombinant Human Fibronectin Construct In Skeletal Muscle Repair And Oxidative Stress

Gemini

A Novel Polypeptide Inhibitor Of MMP-1 Attenuates The UVA-Mediated Skin Aging

Therapeutic

Aging Pathway

A newly developed polypeptide inhibitor effectively reduces UVA-induced skin aging by targeting a key enzyme, improving skin firmness and reducing wrinkles.

Nov 13, 2025

Gemini

Age Differences In Spontaneous Cerebrovascular Reactivity At Rest

Aging Pathway

Older adults, even those without cognitive impairment, exhibit reduced spontaneous cerebrovascular reactivity at rest compared to younger adults, especially in brain regions like the medial temporal lobe.

Nov 13, 2025

Gemini

An Fmri Approach To Assess Intracranial Arterial-To-Venous Cardiac Pulse Delay In Aging

Analytical

A new method using functional MRI can measure the delay between arterial and venous pulsations in the brain, revealing that this delay shortens with age and is faster in men compared to women.

Nov 13, 2025

Gemini

Association Between Biological Aging And Genetic Susceptibility With The Risk Of Bipolar Disorder And Schizophrenia: A Prospective Cohort Study

Analytical

Accelerated biological aging is significantly associated with an increased risk of developing bipolar disorder and schizophrenia, with an even higher risk observed when combined with a strong genetic predisposition.

Nov 13, 2025

Gemini

Aging Pathway

Clonal hematopoiesis of indeterminate potential (CHIP), an age-related condition characterized by acquired mutations in blood stem cells, is linked to an increased risk of developing cardiovascular and kidney diseases.

Nov 13, 2025

Gemini

Combination Antiretroviral Therapy Prevents SIV-Induced Aging In The Hippocampus And Neurodegeneration Throughout The Brain

Therapeutic

Aging Pathway

Combination antiretroviral therapy effectively reverses accelerated brain aging and reduces nerve cell damage caused by simian immunodeficiency virus infection.

Nov 13, 2025

Gemini

Decoding Noncoding Rnas In Regulating Cardiovascular Aging And Age-Related Conditions: The Emerging Landscape

Aging Pathway

Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating cardiovascular aging and associated diseases by influencing both pro-aging and anti-aging processes.

Nov 13, 2025

Gemini

Defective Chaperone-Mediated Autophagy In The Retinal Pigment Epithelium Of Age-Related Macular Degeneration Patients

Aging Pathway

Therapeutic

A specific cellular cleaning process called chaperone-mediated autophagy is found to be defective in the retinal pigment epithelium of patients with age-related macular degeneration, contributing to the disease.

Nov 13, 2025

Gemini

Diagnostic Accuracy Of Sarcopenia Screening Tools In Low-Income Older Adults In Amazonas, Brazil

Analytical

The Ishii test demonstrated the highest diagnostic accuracy for sarcopenia in low-income older adults in the Amazonas region of Brazil.

Nov 13, 2025

Gemini

Dissociation Of The Nuclear Basket Triggers Chromosome Loss In Aging Yeast

Aging Pathway

Aging in yeast causes the nuclear basket to detach from the nuclear pore complex, leading to the asymmetric distribution and loss of chromosomes, a process linked to the leakage of unprocessed genetic material.

Nov 13, 2025

Gemini

Effects Of Protein-Based Multinutrient Therapy On Sarcopenia In Older Adults: A Systematic Review And Meta-Analysis

Therapeutic

Lever

Analytical

Protein-based multinutrient therapy significantly improved handgrip strength, gait speed, and Insulin-like Growth Factor-1 levels in older adults with sarcopenia.

Nov 13, 2025

Gemini

Estrogen Depletion And Immune Activation And Inflammation In Women With HIV

Aging Pathway

Estrogen depletion during menopause in women with HIV alters immune responses, leading to chronic inflammation, increased risk of other health conditions, and the persistence of the HIV reservoir.

Nov 13, 2025

Gemini

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

A comprehensive review summarizes and analyzes the characteristics, methods, and evaluation systems of various rodent models used in late-onset hypogonadism research to guide optimal model selection and development.

Nov 13, 2025

Gemini

Evaluation And Research Progress On Rodent Models Of Late-Onset Hypogonadism: A Comprehensive Review

Aging Pathway

This comprehensive review synthesizes the characteristics, methodologies, and assessment criteria of various rodent models employed in the study of late-onset hypogonadism, critically evaluating their strengths and weaknesses to inform optimal model selection for future research.

Nov 13, 2025

Gemini

Exercise Attenuates Inflammaging And Testosterone Decline In Aged And Morphine-Treated Rats: A Role For NF-Κb Signaling

Aging Pathway

Factors Associated With Risk Of Clonal Haematopoiesis Of Indeterminate Potential: A Systematic Review And Meta-Analysis

Analytical

A systematic review and meta-analysis found that hypertension, HIV infection, and smoking are linked to an increased risk of Clonal Haematopoiesis of Indeterminate Potential (CHIP), while Asian ethnicity is associated with a lower risk, with these associations varying by specific gene mutations.

Nov 13, 2025

Gemini

Therapeutic

The paper suggests that using red and near-infrared light, known as photobiomodulation, may help to slow brain aging, reduce inflammation, and improve overall brain function and quality of life in older adults.

Nov 13, 2025

Gemini

N-Acetylcarnosine Attenuates Age-Associated Declines In Multi-Organ Systems To Improve Survival

Therapeutic

A six-month treatment with N-acetylcarnosine significantly reduced various age-related health issues and extended the lifespan of female mice by approximately 50%.

Nov 13, 2025

Gemini

Neuronal Pentraxin 1 Accelerates Post-Stroke Atherosclerosis By Inducing Endothelial Cell Senescence

Aging Pathway

Therapeutic

A protein called neuronal pentraxin 1 (NPTX1) increases after a stroke and speeds up the development of atherosclerosis, a condition where arteries harden, by causing the cells lining blood vessels to age prematurely.

Nov 13, 2025

Gemini

The Role Of The Sirt1 And Mtor Pathways In Exercise-Induced Β-Cell Senescence Reduction In Type 2 Diabetes Mellitus

Aging Pathway

Lever

Therapeutic

Exercise helps reduce the aging and dysfunction of insulin-producing cells in individuals with type 2 diabetes by activating the SIRT1 pathway and inhibiting the mTOR pathway.

Nov 13, 2025

Gemini

Accelerated Regeneration Of Senescent Bone Injury Through Age- And Sex-Independent Macrophage Polarization

Therapeutic

Aging Pathway

Individuals with the KLOTHO-VS gene variant heterozygosity showed better memory performance, especially in those with early memory impairment and a specific genetic risk factor for Alzheimer’s disease.

Nov 12, 2025

Gemini

Lever

The study successfully developed and implemented a comprehensive food frequency questionnaire for assessing the dietary intake of older Indian adults across diverse regions.

Nov 12, 2025

Gemini

Multi-Omic Profiling Reveals Age-Related Immune Dynamics In Healthy Adults

Aging Pathway

Analytical

A comprehensive study of healthy adults reveals that aging leads to specific changes in T cell gene activity, resulting in a T helper 2 cell bias that impairs B cell responses to vaccines.

Nov 12, 2025

Gemini

NMN Supplementation As A Strategy To Improve Oocyte Quality: A Systematic Review And Transcriptomic Analysis

Therapeutic

Therapeutic

The study compared different methods for extracting beneficial complex sugars from Scorias spongiosa, demonstrating that the chosen extraction technique significantly impacts the amount obtained, their biological effectiveness, and their capacity to offer anti-aging benefits.

Nov 11, 2025

Gemini

Deciphering The Emerging Interrelationship Between Cellular Senescence And Extracellular Vesicles: Implications For Therapy And Diagnosis

Aging Pathway

Therapeutic

Cellular senescence, a process linked to aging and disease, interacts with tiny sacs released by cells called extracellular vesicles, which can either promote or suppress this senescence and may offer new avenues for diagnosis and treatment.

Nov 11, 2025

Gemini

Differential Cognitive Enhancer Effects Of Acetylcholinesterase Inhibitors And Memantine On Age-Related Deficits In Vigilance And Sustained Attention: A Preclinical Validation Study

Therapeutic

This preclinical study demonstrated that different Alzheimer’s disease medications have distinct effects on age-related attention and vigilance deficits in rats, with some improving reaction time and others improving accuracy.

Nov 11, 2025

Gemini

Ejiao Alleviates Sarcopenia By AKT/Mtor/Foxo3A And AMPK Pathways In An Aging Rat Model Induced By D-Galactose Combined With Restricted Movement

Therapeutic

Analytical

A study identified a protein called glial fibrillary acidic protein (GFAP) in both blood and cerebrospinal fluid as a strong indicator that links aging to a higher risk of cognitive decline.

Nov 11, 2025

Gemini

Impact Of Meditation On Brain Age Derived From Multimodal Neuroimaging In Experts And Older Adults From A Randomized Trial

Clock

Lever

Analytical

Long-term meditation practice is associated with an appearance of a younger brain compared to one’s actual chronological age.

Nov 11, 2025

Gemini

Interaction Between Smoking And Olfactory Function On Frailty: A Population-Based Cross-Sectional Study

Analytical

Lever

A study found that smoking and a reduced sense of smell are independently linked to an increased risk of frailty, and when combined, these factors synergistically elevate the risk of frailty even further.

Nov 11, 2025

Gemini

Ketone Catabolism Is Essential For Maintaining Normal Heart Function During Aging

Aging Pathway

Therapeutic

Lever

The body’s ability to break down ketones, a type of fat, is crucial for maintaining healthy heart function as individuals age.

Nov 11, 2025

Gemini

Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-Parp1 Axis-Mediated DNA Repair To Mitigate Intestinal Aging

Aging Pathway

Therapeutic

Researchers found that a molecule produced by the beneficial gut bacterium Lactobacillus salivarius can activate a specific pathway to repair DNA, which helps to slow down the aging of the intestine.

Nov 11, 2025

Gemini

Linker Histone Regulates The Myeloid Versus Lymphoid Bifurcation Of Multipotent Hematopoietic Stem And Progenitors

Aging Pathway

Therapeutic

Linker histones play a crucial role in directing multipotent hematopoietic stem and progenitor cells towards either myeloid or lymphoid cell types by influencing how DNA is packaged and accessed.

Nov 11, 2025

Gemini

Piezo1 Activation Suppresses Bone Marrow Adipogenesis To Prevent Osteoporosis By Inhibiting A Mechanoinflammatory Autocrine Loop

Aging Pathway

Aging Pathway

Depleting telomerase in zebrafish accelerates various hallmarks of brain aging, including increased inflammation, impaired blood-brain barrier function, and heightened anxiety-like behavior.

Nov 11, 2025

Gemini

Analytical

Reproductive factors such as the number of biological children, age at menarche, history of abortion, and age at menopause are significantly linked to the risk of frailty in middle-aged and older women.

Nov 10, 2025

Gemini

Benchmarking Large Language Models For Personalized, Biomarker-Based Health Intervention Recommendations

Analytical

Large language models show limited suitability for providing unsupervised personalized longevity intervention recommendations based on biomarker profiles, despite proprietary models outperforming open-source ones in comprehensiveness.

Nov 10, 2025

Gemini

Analytical

A study found that a higher systemic inflammation response index, a measure of the body’s inflammatory state, is linked to an increased risk of chronic kidney disease, and that shorter leukocyte telomere length, a marker of cellular aging, partially accounts for this connection.

Nov 10, 2025

Gemini

Analytical

Quantitative MRI can detect microstructural changes in the hippocampus, such as demyelination and iron deposition, that are associated with both healthy aging and early Alzheimer’s disease pathology.

Nov 10, 2025

Gemini

Ribosome Dysregulation And Intervention In Age-Related Infertility

Aging Pathway

Therapeutic

A recent study found that age-related infertility in women is associated with increased activity of genes responsible for making ribosomes in egg cells and surrounding support cells, and that a drug called rapamycin can improve embryo quality and pregnancy success in women experiencing infertility.

Nov 10, 2025

Gemini

Sex Differences In The Association Between Heavy Metal Exposure And Frailty In The U.S. Adults: A Cross-Sectional Analysis

Analytical

Exposure to heavy metals such as lead and cadmium is linked to an increased risk of frailty in U.S. adults, with women experiencing a more significant impact.

Nov 10, 2025

Gemini

Aging Pathway

A protein found in the seminal fluid of male C. elegans worms, called SFP-1, is transferred to hermaphrodites during mating and causes them to age faster and deplete their fat reserves.

Nov 10, 2025

Gemini

Analysis Of Immune Cell Remodeling And Functional Alterations Induced By Aging And Obesity In Mice

Analytical

Aging and obesity collectively alter the immune system, leading to persistent inflammation and reduced effectiveness of key immune cells.

Nov 9, 2025

Gemini

Deciphering The Nexus Of Aging And Pan-Cancer: Single-Cell Sequencing Reveals Microenvironmental Remodeling And Cellular Drivers

Aging Pathway

Analytical

Therapeutic

Single-cell sequencing has revealed that aging remodels the tumor microenvironment by accumulating senescent cells and diminishing anti-tumor immunity, thereby fueling cancer development and progression.

Nov 9, 2025

Gemini

Lever

Older Chinese adults who performed less frequent housework showed a higher risk of developing cognitive impairment.

Nov 6, 2025

Gemini

Cognitive Predictors Of Functional Status Transitions Among Older Adults With Seven-Year Follow-Up: A Latent Transition Analysis

Analytical

A seven-year study revealed that a strong sense of orientation is the most consistent cognitive factor protecting older adults from losing their ability to perform daily tasks.

Nov 6, 2025

Gemini

Design And Synthesis Of Senescence-Targeted Prodrugs With Senomorphic And Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury

Therapeutic

Researchers have designed a new type of drug that can selectively eliminate harmful senescent cells and suppress the damaging secretions of other senescent cells, showing promise in mitigating kidney injury caused by chemotherapy.

Nov 6, 2025

Gemini

Electroacupuncture Plus Exercise For Sarcopenia In Older Adults: Protocol For A Randomized, Controlled, Assessor-Blinded Trial

Therapeutic

Aging Pathway

A longer duration of an intact hypothalamic-pituitary-gonadal axis reduces the adverse effects of late-life frailty and associated mortality risk in male dogs.

Nov 6, 2025

Gemini

Multi-Omics Analysis Of Testis After Long-Term Exposure To Polystyrene Nanoplastics Reveals Premature Testicular Aging And Age-Dependent Damage In Mice

Aging Pathway

Analytical

Long-term exposure to polystyrene nanoplastics leads to premature testicular aging in young mice and more severe testicular damage in older mice.

Nov 6, 2025

Gemini

Analytical

Longitudinal research indicates that declines in physical and cognitive abilities generally emerge before changes in social functioning, with no distinct order found for emotional well-being.

Nov 6, 2025

Gemini

Wide-Band Electrical-Impedance-Spectroscopy Integrated Microfluidic Organism-On-A-Chip Device For Simultaneous Monitoring Of Multi-Organ Degradation Along C. Elegans Aging

Analytical

A novel microfluidic device integrated with electrical impedance spectroscopy has been developed to simultaneously monitor the degradation of multiple organs in C. elegans as they age.

Nov 6, 2025

Gemini

Therapeutic

A new delivery system using limosomes enhanced with ascorbyl palmitate and hyaluronan effectively transports the antioxidant Fisetin into the skin, significantly reducing signs of UVB-induced photoaging and inflammation.

Nov 5, 2025

Gemini

Fundc1 Deficiency Aggravates Endothelial Senescence And Retinal Dysfunction

Aging Pathway

Therapeutic

A lack of the protein FUNDC1 worsens the aging of blood vessel lining cells and contributes to the decline in retinal function.

Nov 5, 2025

Gemini

Analytical

A study using data from the Dog Aging Project identified specific protein breakdown products in the blood, called post-translationally modified amino acids, as reliable indicators of aging in dogs, with kidney function mediating about half of their age-related increase.

Nov 5, 2025

Gemini

Recombinant Type I & III Chimeric Collagen Significantly Enhances The Vitality Of Fibroblasts And Decelerates The Skin Aging Process

Therapeutic

A newly developed dual-function recombinant collagen, combining elements of type I and type III collagens, effectively boosts skin cell activity and reduces visible signs of aging.

Nov 5, 2025

Gemini

The aging of the immune system, known as immunosenescence, plays a crucial role in shaping the development and progression of various blood-related disorders, impacting both disease risk and the effectiveness of treatments.

Nov 4, 2025

Gemini

O304 Is A Mitochondrial Uncoupler Which Extends C. Elegans Lifespan And Induces Vasorelaxation Of Rat Mesenteric Arteries

Lever

Therapeutic

A compound designated O304 has been found to extend the lifespan of C. elegans worms and relax rat blood vessels by acting as a mitochondrial uncoupler.

Nov 4, 2025

Gemini

Obstructive Sleep Apnea And Aging Of The Cardiovascular System: A Multidimensional Analysis Of The Mechanisms Involved

Aging Pathway

Obstructive sleep apnea accelerates the aging of the cardiovascular system through multiple pathways, including cellular senescence, mitochondrial dysfunction, metabolic dysregulation, telomere attrition, impaired intercellular communication, and adipose tissue senescence.

Nov 4, 2025

Gemini

P-Selectin Overexpression Impairs Hematopoietic Stem Cell Homeostasis Via Inflammatory Receptor-Mediated Proliferation And Differentiation

Aging Pathway

Overexpression of P-selectin impairs the ability of hematopoietic stem cells to maintain a healthy blood and immune system by causing them to over-proliferate and differentiate prematurely, particularly during aging and inflammation, but it also shows potential to inhibit leukemia stem cells.

Nov 4, 2025

Gemini

Phenotypes, Mechanisms, And Therapeutic Strategies Of Natural Killer Cell Immunosenescence

Therapeutic

This paper reviews the characteristics, underlying processes, and potential treatments for the age-related decline in function of natural killer immune cells, which are crucial for fighting infections and tumors.

Nov 4, 2025

Gemini

Profile Of Biological Aging In First Primary Cancers: A Pan-Cancer Analysis Of Two Large-Scale Cohorts From The UK And Hong Kong

Clock

Analytical

Biological aging that progresses faster than a person’s chronological age is associated with an elevated risk of developing various cancers, with a particularly strong link to lung cancer incidence and mortality.

Nov 4, 2025

Gemini

Reproductive Fitness And The Links To Chronic Disease And Systemic Aging

Aging Theory

Female reproductive aging is the earliest indicator of aging in humans, and reproductive health, including normal transitions and disorders, significantly influences long-term systemic health and the risk of chronic diseases.

Nov 4, 2025

Gemini

Single-Cell RNA Sequencing Identifies Accumulation Of Fcgr2B + Virtual Memory-Like Cd8 T Cells With Cytotoxic And Inflammatory Potential In Aged Mouse White Adipose Tissue

Aging Pathway

Single-cell RNA sequencing revealed that aging in mice leads to an accumulation of a specific type of immune cell, called Fcgr2b+ virtual memory-like CD8 T cells, within white adipose tissue, which possess the ability to cause both cell damage and inflammation.

Nov 4, 2025

Gemini

Spatiotemporal Transcriptomic Characteristics Of Immune And Metabolic Dysregulation During Mouse Brain Aging

A comprehensive study mapped gene activity across different mouse brain regions throughout the aging process, revealing distinct patterns of immune system activation and metabolic changes over time.

Nov 4, 2025

Gemini

Aging Pathway

Loss of the protein ZC3H4 disrupts mitochondrial function, leading to changes in prostate stromal cells that contribute to cellular aging, altered cell binding, and resistance to cell death, mimicking aspects of prostate enlargement.

Nov 4, 2025

Gemini

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway.

Aging Pathway

A compound called 20(S)-protopanaxadiol was found to extend the lifespan and improve stress resistance in Caenorhabditis elegans worms by acting on the insulin/IGF-1 signaling pathway.

Nov 3, 2025

Gemini

A novel miRNA-TF-mRNA regulatory network associated with cellular senescence in osteoporosis.

Aging Pathway

Researchers have used an advanced proteomic technique to identify previously unknown intact protein forms and their modifications in the secretions of senescent cells, including potential new biomarkers for aging.

Nov 3, 2025

Gemini

Correlations between Aging, Telomeres, and Natural Compounds.

The paper investigates the intricate relationship between the aging process, the protective caps on chromosomes called telomeres, and the potential therapeutic effects of various natural compounds in promoting a longer and healthier life by influencing age-related cellular pathways.

Nov 3, 2025

Gemini

Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress.

Lever

Embryonic stem cell-derived extracellular vesicles can delay the aging of cells by inhibiting oxidative stress, a process that damages cells.

Nov 3, 2025

Gemini

High-fat diet attenuates vestibular and auditory dysfunction in aged mice via macrophage-mediated anti-inflammatory mechanisms.

Lever

Aging Pathway

A high-fat diet was found to slow down the decline of both balance and hearing abilities in aged mice by promoting immune cells that reduce inflammation.

Nov 3, 2025

Gemini

Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Aging Pathway

Normal aging leads to an increase in amyloid beta protein fragments and the activity of a specific enzyme called beta-secretase in the brains of rodents and humans.

Nov 3, 2025

Gemini

Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease.

Aging Pathway

Chronic low-grade inflammation and the accumulation of senescent cells are key drivers of detrimental structural changes in the heart and blood vessels, contributing significantly to age-associated cardiovascular diseases.

Nov 3, 2025

Gemini

LCN2 promotes HEI-OC1 cells senescence via activating NF-κB signal pathway in presbycusis.

Aging Pathway

A study found that a protein called LCN2 promotes the aging of inner ear cells by activating a specific signaling pathway, contributing to age-related hearing loss.

Nov 3, 2025

Gemini

Near infrared LED irradiation reverses the declining quality of mice post-ovulatory aging and reproductive aged oocytes†.

Lever

Near-infrared LED light exposure has been shown to improve the quality of aged mouse egg cells by revitalizing their cellular energy powerhouses.

Nov 3, 2025

Gemini

Revealing the Interplay of Intraorganellar O₂^•- and ATP in Brain Aging-Related Alzheimer’s Disease via Unimolecular Dual-Responsive Probes.

Researchers developed tools to observe the interplay of a damaging molecule called superoxide and the cell’s energy currency, ATP, within brain cell compartments, finding that aging cells affected by Alzheimer’s-related proteins experience an imbalance where damaging superoxide increases before ATP decreases.

Nov 3, 2025

Gemini

Sirolimus Use In Allogeneic Hematopoietic Cell Transplant Recipients: Assessing Its Senotherapeutic Role In A High Risk Population

Analytical

Therapeutic

The study investigated whether sirolimus, when used at standard doses to prevent complications after allogeneic hematopoietic cell transplantation, demonstrates a significant anti-aging effect by reducing cellular senescence.

Nov 3, 2025

Aging Theory

Skeletal muscle aging commences during middle age with subtle molecular alterations, preceding the noticeable loss of muscle mass and function.

Nov 2, 2025

Gemini

Welcome To Aging Papers

This website will host summaries of the most recent scientific papers published about aging. It will be updated daily.

Oct 26, 2025

Categories